德克萨斯理工大学徐长学等 | 关于3D生物打印中细胞沉降问题的观点

内容简介

本观点论文聚焦3D生物打印中的细胞沉降问题炒币。3D生物打印通过对于生物墨水的逐层精确定位来制造3D人造组织/器官。尽管近些年3D生物打印已经被越来越多地用于组织工程和再生医学，3D生物打印仍然面临许多挑战，例如打印过程中的细胞沉降问题。生物墨水，作为3D生物打印中的重要元素，通常由生物材料和活性细胞组成。当细胞所受到的重力大于细胞所受到的浮力时，细胞将在重力的驱使下沉降并堆积在生物墨水容器的底部，这将会加剧细胞的凝聚并影响打印精度和可靠性。本文总结了前人提出的细胞沉降的问题，讨论了细胞沉降的机理，表征了细胞沉降的行为，并总结了潜在的有效缓解细胞沉降的方法。

文章导读

图1 细胞沉降以及细胞凝聚对于喷墨式3D生物打印性能的影响

图2 细胞沉降的表征

展开全文

图3 几种典型的缓解细胞沉降的方法

参考文献

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Bio-Design and Manufacturing（中文名《生物设计与制造》），简称BDM，是浙江大学主办的专业英文季刊，主编杨华勇院士、崔占峰院士，2018年新创，目前已被SCI-E等检索，最新影响因子为5.887炒币。

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